Advances in immunotherapy rely on targeting novel cell surface antigens, including therapeutically relevant peptide fragments presented by HLA molecules, collectively known as the actionable immunopeptidome.Although the immunopeptidome of classical HLA molecules is extensively studied, exploration of the peptide repertoire presented by non-classica
Abstract A lack of stability in the expression of Bacillus thuringiensis genes (CRY) and the dialaninophosphate resistance gene (BAR) in transgenic rice plants can lead to the loss of important characters.The genetic stability of transgenic expression in high-generation lines is thus critically important for ensuring the success of molecular breedi
Purpose: To report panuveitis with exudative retinal detachments in a healthy 27-year-old woman with biallelic mutations in the RPE65 gene, who underwent bilateral sequential gene therapy with subretinal administration of voretigene TV Connect neparvovec-rzyl.Observations: Visual acuity improved for 30 days after surgery as oral corticosteroids wer